Well, I have an Africa Twin, for several months now. My take is that I REALLY miss the cruise control, and the drive shaft, and on the other hand, losing 100 pounds is amazing. I have nothing bad to say about S10's, it was a fantastic bike. While most of my riding is street, the occaisional dirt ride requires a bit less caution going around curves and gravel sections. I did manage the Alpine Loop on my S10, but it was a handful. Would have been a LOT better if I would have remembered to TURN OFF THE TRACTION CONTROL. That came close to dumping me 2 or 3 times on the Alpine Loop. That is a must on any bike for sure.
I would agree with those who say the S10 is a little better at freeway speeds, perhaps a tiny bit "less buzzy" and feels a bit more solid.
I have dealt with the lack of cruise control by installing one of the throttle locks. Have adapted to it and it does sort of fill in for that loss. As far as the chain drive, well, I guess that is just the price of losing some pounds. It is more trouble, but for me not a deal breaker. Have adjusted chain twice in 3,000 miles.
I would say both the S10 and the AT have their own advantages. I wish would have test ridden the dual clutch version, am curious about it........