snakebitten said:. . .
But it seems there should be noticeable difference between engines that do get the treatment and those that don't?
You bet!
The follow photo is from the Nissan pickup I sold last year. The injector and intake port on the left show the results of running no additive for about 80,000(iirc) miles. It's a sticky tar lining everything through-out the system. The injector and port on the right I'd just cleaned and looks like what Jaxxon found at 45,000 in the customer bike.