This is a route I really want to do on my Tenere while in Colorado. I've done it several times om my 530, its no big deal. Maybe a bit more challenging on the Tenere and slower. But IMO this is the best Adventure route by far in that part of Colorado. MapQuest says 16+ hours, thats way overstated, it is a long day for sure,, maybe 8 hours with lunch somewhere, depends on picture takin and flower sniffin! I figured there were at least a few others that would really enjoy this ride as well. I'll probably ride it a couple times while I'm there!
One thing....the road on the map stops just before the top of Imogene Pass for some reason, but it really does gone on over the top. From the top at Imogene Pass its only 10-12 miles to Ouray.
All this also depends on if the roads are open or not!
http://mapq.st/11rDJe9