I had a rear spoke lose it's nipple. Thankfully, it fell out as I was moving it on my front sidewalk so I heard it and thankfully found the nipple. I say "thankfully" because I know it woulda ruined the swingarm,,,, and I hear that you have to buy complete sets from Ma Yamaha. If memory serves, I had around 8K miles on it at the time, maybe less. Can't remember for sure though. When I addressed the issue, I found quite a few on the rear wheel loose, some very loose. The front had a few loose, but not near as many are the rear and the one's that were loose, were not "as loose". Once tightened up with the click wrench I zipped tied them all just in case.
At around 10K miles I changed out the rear tire for the first time and took the opportunity to recheck. Found a few on the rear that has loosened up a smidge but not as bad and not near as many. Front stayed roughly the same. I just changed out the rear again {13.5K miles} and damned if there wasn't another couple loose again. The front had a couple loosen up too. I was hoping this issue would go away once they "settled in". Next time I swap tires, front or back I will be placing loc tite on the ends hoping it wicks in enough to lock them in place,,, or at least keep the nipple from coming completely off in the even they do loosen up a lot.