The Anakee Adventures on my 2015 ST are now at 6600 mi with about 3mm tread depth left on the rear and 3.5 mm on the front. I figure the rear will be worn out around 8K miles. They've been ridden mostly on paved backroads around the Pacific Northwest with occasional unpaved sections.
Except for the wear, which is a lot less than several sets of Anakee III rears that went 11-12K for me, I generally like the tire. The wear profiles are still reasonably round at 6600 mi; they run smoothly with good grip on wet or dry twisty roads, perform well at highway speeds, and feel comfortable on graveled roads. It's too early to know, but I suspect the fronts won't outlast the rears by a lot, and that's disappointing because most front tires I've used on 2 STs have outlasted the rears by about 2:1 (the Anakee III's being an exception).
These are the first 80:20 tires on the ST for me. I tried Mitas E-07 tires but didn't really nead a 50:50 tire and was disappointed at the mileage -rear centers wore smooth at 10K mi. I also tried Dunlop Roadsmart 3's, which are 100% highway tires, and thought they performed well, but again was disappointed at the mileage -only 7400 on the rear.